The active form of folate
Most folate supplements use folic acid — the synthetic form. Your body has to convert folic acid into the active L-methylfolate before it can be used. About 1 in 3 women carry the MTHFR gene variant, which slows that conversion significantly.
Quatrefolic® is the patented bioactive form of L-methylfolate. No conversion needed. Used directly by cells from the moment it's absorbed.
Why $35.90 when others are $10?
Most $10 folate supplements use folic acid. The conversion-to-active step matters — without it, the supplement doesn't deliver its full benefit, especially for women with MTHFR variants.
Quatrefolic® is the patented active form developed by Gnosis (Italy), used in clinical research. ZeinPharma manufactures this product in Germany to EU GMP pharmaceutical standards.
The price reflects three things: the patented Quatrefolic raw material, German pharmaceutical-grade manufacturing, and a 4-month supply (120 capsules at 1/day).
What it supports
• Supports maternal tissue growth during pregnancy
• Folate intake during pregnancy supports normal maternal folate status
• Supports normal blood formation
Suitable as part of a balanced daily routine throughout preconception, pregnancy, and breastfeeding.
When to take it
Take 1 capsule daily with water, with or without food. Begin at least 4 weeks before trying to conceive. Continue throughout pregnancy and breastfeeding, or as advised by your healthcare professional.
Made in Germany
Manufactured by ZeinPharma in Germany to EU GMP pharmaceutical standards. Quatrefolic® raw material sourced from Gnosis (Italy). Imported and shipped from Singapore by Hanseatic Healthcare.
Frequently asked questions
How is this different from folic acid?
Folic acid is the synthetic form — your body must convert it to the active L-methylfolate before it can be used. Quatrefolic is already in the active form. No conversion step. This matters most for the ~33% of women with MTHFR genetic variants who can't convert folic acid efficiently.
What is MTHFR?
MTHFR is a gene that codes for an enzyme that converts folic acid into the active L-methylfolate. About 1 in 3 women have variants that slow this conversion. Quatrefolic bypasses the conversion entirely — relevant whether you know your MTHFR status or not.
Can I take this during pregnancy?
Yes — folate is recommended throughout preconception, pregnancy, and breastfeeding. Always check with your doctor or midwife before starting any new supplement during pregnancy.
Is this vegan?
Yes — vegan, gluten-free, lactose-free. HPMC (vegan) capsule shell.
How is it different from Avitale Folsäure 400/800?
Both products provide folate, but in different forms. Avitale uses folic acid (the synthetic form) plus iodine and B12 in one tablet. ZeinPharma uses Quatrefolic (the patented active L-methylfolate) without added iodine and B12. If you have known MTHFR variants or prefer active forms, choose ZeinPharma. If you want the all-in-one preconception formula with B12 + iodine, Avitale Bundle is the choice.
Where is it made?
Manufactured by ZeinPharma in Germany. Imported and shipped from Singapore by Hanseatic Healthcare.
Important information
This product is a health supplement and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare professional before use, especially if pregnant, breastfeeding, or taking medication. Keep out of reach of children. Store in a cool, dry place.